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Carbimazole works by preventing iodine from coming together with other components to form thyroid hormones.

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Although both liothyronine (T3) and T4 can be elevated in hyperthyroidism, serum T4 levels are primarily used in diagnosis.

The main principle of treatment is to administer the lowest dose of antithyroid drugs needed for controlling clinical symptoms, with the aim of restoring normal maternal thyroid function but ensuring that fetal thyroid function is minimally affected.

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Two cases, ages 62 and 75 years, had onset of jaundice 3 and 5 weeks after starting antithyroid medications, with prolonged cholestasis in patient in whom methimazole was continued).

Others who have been treated successfully develop an underactive thyroid gland (hypothyroidism) in the future.

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